Women were older (68

Women were older (68.3??18.0 vs. men. Among women, 276 (22.8%) experienced the primary outcome, including 161 (13.3%) transfers to an intensive care unit and 115 (9.5%) deaths without transfer to intensive care unit. The rate of in-hospital death or transfer to an intensive care unit was lower in women versus men (crude hazard ratio [HR]: 0.62, 95% confidence interval [CI]: 0.53C0.72). Age (adjusted HR: 1.05 per 5-year increase, 95% CI: 1.01C1.10), body mass index (adjusted HR: 1.06 per 2-unit increase, 95% CI: 1.02C1.10), chronic kidney disease (adjusted HR: 1.57, 95% SERPINA3 CI: 1.11C2.22) and heart failure (adjusted HR: 1.52, 95% CI: 1.04C2.22) were independently associated with the primary outcome in women. Elevated B-type natriuretic peptide/N-terminal prohormone of B-type natriuretic peptide (adjusted HR: 2.41, 95% CI: 1.70C3.44) and troponin (adjusted HR: 2.00, 95% CI: 1.39C2.88) concentrations at admission were also associated with the primary outcome, even in women free of previous coronary artery disease or heart failure. Conclusions Although female sex was associated with a lower risk of transfer to an intensive care unit or in-hospital death, COVID-19 remained associated with considerable morbimortality in women, especially in those with cardiovascular diseases. strong class=”kwd-title” Keywords: COVID-19, SARS-CoV-2, Women, Outcomes, Risk Moxisylyte hydrochloride factors strong class=”kwd-title” Abbreviations: BNP, B-type natriuretic peptide; CI, confidence interval; COVID-19, coronavirus disease 2019; HR, hazard ratio; ICU, intensive care unit; NT-proBNP, N-terminal prohormone of B-type natriuretic peptide; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 Rsum Justification Bien que les femmes constituent prs de la moiti des patients hospitaliss pour une contamination COVID-19, il na pas t report de donnes spcifiques dans cette populace. Objectifs valuer la frquence et limpact des comorbidits cardiovasculaires chez les femmes atteintes de la COVID-19. Moxisylyte hydrochloride Mthode Tous les patients hospitaliss de fa?on conscutive pour une contamination COVID-19?dans 24?h?pitaux ont t inclus conscutivement entre le 29?fvrier et le 20?avril 2020. Le critre de jugement principal est le transfert en unit de soins intensifs ou al survenue dun dcs intra-hospitalier. Rsultats Parmi les 2878?patients, 1212 (42,1?%) taient des femmes. Les femmes taient plus ages (68,3??18,0?vs 65,4??16,0?ans, em p /em ? ?0,001) mais prsentaient moins de comorbidits cardiovasculaires par rapport aux hommes. Parmi les femmes, 176 (22,8?%) ont prsent un vnement incluant 161?patients (13,3?%) ont d? tre transfres en unit de soins intensifs et 115 (9,5%) sont dcdes, sans transfert dans une unit de soins intensifs. Le taux de dcs intra-hospitaliers ou de transferts dans une unit de soins intensifs tait moindre chez les femmes comparativement aux hommes (HR brut?: 0,62, IC95?%?: 0,53C0,72). Lage (HR ajust?: 1,05 par tranche de 5 ans, IC95?%: 1,02C1,1), linsuffisance rnale chronique (HR ajust?: 1,57, IC95?%?: 1,11C2,22) et linsuffisance cardiaque (HR ajust: 1,52, IC95?%?: 1,02C2,22) taient indpendamment associs avec la survenue du critre de jugement principal chez la femme. Une lvation du peptide natriurtique (BNP) ou du NT-pro-BNP (HR ajust?: 2,41, IC95?%?: 1,73C3,44) et une lvation de la troponine (HR ajust?: 2,00, IC95?%?: 1,39C2,88) Moxisylyte hydrochloride ladmission taient galement associs avec la survenue du critre de jugement principal, y compris chez les femmes nayant pas de maladie coronaire ou dinsuffisance cardiaque avre. Conclusion Bien que le sexe fminin soit associ avec un risque moindre de transfert en unit de soins intensifs ou de survenue de dcs hospitalier, la COVID-19?associe une augmentation de la morbi-mortalit chez la femme en particulier chez celle Moxisylyte hydrochloride ayant une maladie cardiovasculaire sous-jacente. strong class=”kwd-title” Mots cls: COVID-19, SARS-CoV-2, Femmes, Rsultats, Facteurs de risque Background The world is usually facing the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contamination. Despite unprecedented reorganization of health resources and sanitary steps in most countries, hundreds of thousands of Moxisylyte hydrochloride people have already died worldwide, and new wave(s) and seasonal re-emergence are feared [1], [2], [3]. The main characteristics and profiles of patients hospitalized for COVID-19 have been reported in case series from China [4], [5], Europe [6], [7], [8], [9] and the USA [10], [11], [12]. The association between cardiovascular comorbidities and the prognosis of COVID-19 was soon exhibited [13], [14], [15], [16]. Hypertension, diabetes, chronic kidney disease and other cardiovascular diseases have been associated with a significantly increased risk of death [17], [18], [19], [20]. Furthermore, male sex has been identified as a risk for severe clinical presentation of COVID-19, with men representing up to 80% of patients admitted to an intensive care unit (ICU) [8], [9]. However, although women accounted for 40C50% of patients in main series [4], [11], [12], [21], no specific data have been reported so far in this populace. Through.